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Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high‐fat diet as studied by nontargeted LC‐MS metabolomics approach - Pekkinen - 2013 - Molecular Nutrition

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Orthogonal validation of NMR fragment hit 27 Encouraged by the relatively high binding affinity of compound 27 compared to expectations for fragments, we synthesised a series of analogues to explore the effect of modifying both the sulfonic acid and the ethoxy substituents on binding affinity (Table 1)