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The long C-terminal domain interacts with several intracellular TJ proteins, such as ZO proteins, which are required to link occludin to the actin cytoskeleton [24]
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Early stage atherosclerosis may involve normal and perhaps increased LAL activity leading to cytosolic lipid droplet accumulation, whereas later stages of atherosclerosis may have an acquired dysfunction in LAL hydrolytic activity leading to lysosomal lipid sequestration
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