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Knockout of mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 (mtGPAT1), a major hepatic glycerol-3-phosphate acyltransferase, decreased de novo DAG generation protecting mice from hepatic insulin resistance (195)
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266,267 Excessive ROS levels lead to oxidative damage to DNA, proteins, and lipids, resulting in neuronal apoptosis and impaired nerve function
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