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However, under intense oxidative stress, the collapse of mitochondrial redox balance can reduce Grx2 activity or alter its catalytic specificity, thereby favoring the accumulation of glutathione-conjugated proteins [179]
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For example, amphotericin B, an antifungal with high toxicity and low solubility, was included in cyclodextrins in order to improve solubility and reduce adverse effects [39]
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