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In these studies, diminished levels of GSH increase oxidative stress in whole cells as well as in mitochondrial fractions, and increase lipid peroxidation, intracellular calcium, and gamma-glutamyl transpeptidase (γGT) activity
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Dietary supplements, including green tea extract (particularly when standardized to have a high catechin concentration) and kava, black cohosh, high-dose curcumin, and some Chinese herbal preparations, are implicated in hepatocellular injury, cholestasis, or fulminant hepatic failure in both single case reports and small clinical series
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