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Tumor radioresistance, in which there is limited cell death following exposure to therapeutic ionizing radiation, is thought to result from several distinct mechanisms, including the proliferation of cancer stem cells (CSCs) leading to tumor regrowth following treatment [17]

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In humans receiving ellagitannin-rich pomegranate extract (1 g), peak plasma concentrations of urolithin A glucuronide reached over 80-fold the C max of ellagic acid (2.47 μM compared to 0.02–0.061 μM), indicative of greater bioavailability of the microbial metabolite (Seeram et al., 2008)