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Working with residual internal mammary artery rings from twelve elective coronary artery bypass graft procedures, they recorded concentration-dependent reduction of phenylephrine-induced contraction across 0.01 to 1 milligram per milliliter, significantly greater where the endothelium was left intact

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Reported side effects in human anecdotal use are generally mild and may include: • Mild nausea, particularly with oral administration • Redness, itching, or irritation at the injection site • Temporary dizziness or mild headache • Changes in appetite or weight A significant theoretical concern revolves around its pro-angiogenic properties