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The binding of the antibody and antagonist receptors can prevent dimerization, kinase activation, and downstream signaling, resulting in decreased proliferation and death ( Cancer-Immunity Cycle A series of progressive events must be initiated to enable innate and adaptive immune responses to kill tumor cells effectively

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Notably, past studies have linked CJC-1295 to mild side effects such as injection site pain, itching, swelling, headaches, and diarrhea, all of which tend to subside following discontinuation of therapy