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Despite these limitations, the available evidence suggests that non-medical AAS use is associated with substantial multi-organ health risks, underscoring the need for well-designed prospective observational studies, improved surveillance of non-medical androgen use, and the development of targeted preventive and educational programmes for high-risk groups

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In this regard, a major hydrogen peroxide detoxifying system in plant cells under abiotic stressors is the ascorbate-glutathione cycle, in which ascorbate peroxidase (APX) isoenzymes play a key role in catalyzing the conversion of H 2 O 2 into H 2 O, using ascorbate as a specific electron donor [51,52], particularly in the chloroplast (Figure 3)