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Some essential properties for AVPs include hydrophobicity, which is considered essential for targeting enveloped viruses specifically, as well as high target specificity, which is required for all types of AVPs to be effective [62]
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However, a phase II study of the same combination in patients with NSCLC harboring activating EGFR mutations was terminated early due to inferiority in the linsitinib arm, together with increased toxicity that necessitated erlotinib dose reductions and discontinuations [189]
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