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Activated STAT entering the nucleus promotes the transcription of SOCS, which has a negative regulatory effect on JAK/STAT signaling by inhibiting STAT receptor binding, inactivating JAK through N-terminal kinase inhibition, or binding and ubiquitinating JAK or STAT for proteasomal destruction ( Figure 1 2.3 JAK/STAT pathway and melanocortin system The melanocortin system is a complex signaling system composed of multiple hormones, neuropeptides, and receptors, which exerts a widespread regulatory role in the physiological and pathological processes in the body