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Spadin's discovery established a new research target: TREK-1, a two-pore domain (K2P) background potassium channel first functionally characterized in the brain by Heurteaux and colleagues in 2004 in EMBO Journal , as a plausible pharmacological lever for mood regulation
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No single or dual-agonist compound can replicate the combined effects on appetite regulation, insulin secretion, lipolysis, and thermogenesis that retatrutide produces in research settings
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