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Animals This study was approved by the University of Maryland, Baltimore, Animal Care and Use Committee

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When administered in a fixed 1:1 ratio based on ED 50 equivalence, the pregabalin–thioctic acid combination (0.15–1.2 mg/kg + 3.6–28.8 mg/kg, respectively) yielded intermediate efficacy, with the 1.2 + 28.8 mg/kg dose producing the most sustained threshold elevation (Figure 1C)