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Conversely, recovery from desensitization was slowed by a phosphatase inhibitor under conditions of impaired arrestin association ( β -arrestin2 knockout plus GRK inhibitor, Dang et al., 2011)
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However, the drug combination did not exhibit any enhanced effect on cell thermogenesis and these proteins in vitro , whereas combination of norepinephrine and metformin-induced an additive upregulation of mitochondrial function-related proteins
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