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it is highly expressed in the liver, present in kidney, and upregulated in numerous cancers, so systemic inhibition touches many tissues at once, which is a double-edged property — potential benefits in liver fat (as the 2024 mouse data suggest) but also the reason broad safety questions cannot be waved away
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Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacologic ascorbate in cancer therapy
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