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The identification of an interface involving the first 20 amino acids of BNIP3 in hydrophobic interactions provided the basis for the design of an 8 amino acid long BNIP3 antagonist peptide, WVELHFFN, which has been demonstrated to efficiently protect mitochondria

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Of note, two theories, namely the ‘two-hit’ (6) and ‘multiple parallel hit’ (7), have been proposed to explain the development of NAFLD/NASH