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In conclusion, we found that metformin may alleviate the pathological progression of OA primarily by activating Nrf2 signaling pathway, thereby confirming the promising potential of metformin as a treatment paradigm for OA

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However, the silencing of BolA2 expression not only failed to induce a similar phenotype, but the co-silencing of Grx3 and BolA2 rescued the iron starvation phenotype to some degree (unpublished own data)