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Full article: Expanding the role of alpha lipoic acid for psychiatric and neurological health

In vivo studies in humans have shown that skeletal muscle insulin resistance fuels hepatic lipid accumulation by causing the diversion of substrates from ingested carbohydrates away from skeletal muscle glycogen synthesis toward hepatic DNL (102, 103)

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in effect, the sensory filter ‘disintegrates’ : “Based on this literature and observations from our own laboratory and others on the role of astroglial cells in the fine-tuning of glutamate neurotransmission we present the hypothesis that the proinflammatory cytokines tumor necrosis factor- α , IL-1 β and IL-6 could be involved in the pathophysiology of mental fatigue through their ability to attenuate the astroglial clearance of extracellular glutamate, their disintegration of the blood brain barrier, and effects on astroglial metabolism and metabolic supply for the neurons, thereby attenuating glutamate transmission