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Mitochondria play important roles in free radical generation, ATP formation, and apoptosis [15]
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In particular, TMAO was shown to trigger platelet activation and thrombosis via increasing the platelet responsiveness by enhancing stimulus (ADP, collagen, thrombin, or arachidonic acid)-dependent mobilization of intracellular Ca 2+ stores in platelets (Zhu et al., 2016
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