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Similarly, the pharmacological activity and tolerability of the FGFR-2 inhibitor pemigatinib are being investigated as monotherapy or in combination with other anticancer drugs in patients with advanced tumors including breast cancer in phase I/II study (NCT02393248)
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4a), and pharmacologic inhibition of LAT1 suppresses mTOR signaling and tumor growth (e.g., non-small cell lung cancer, oral cancer) 124,125
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