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Overall, the true goal of targeting the PCD pathway is not simply to “inhibit cell death,” but to reprogram the pulmonary immune microenvironment through finely tuned regulation of death programs across different cell types and disease stages, advancing COPD treatment from “blocking damage” to a novel immunotherapy paradigm of “rebuilding homeostasis.” Statements Author contributions JX: Writing – original draft, Writing – review & editing
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Endocrinology, 112(5), 1613-1617
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