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Aβ1–42 fibrils composed of two intertwined protofilaments determined by cryo-electron microscopy suggested an overall “LS”-shaped topology of individual subunit ( FIGURE 3 In the case of Parkinson’s disease-associated α-synuclein, early studies by Heise and Baldus demonstrated the use of 13 C and 15 N SSNMR chemical shifts to decipher the presence of two different α-synuclein conformations correlated with the fibril morphology (Kloepper et al., 2007
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