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Thus, both amino acids and the PI3K–Akt pathway involving growth factors are considered to be necessary for the activation of mTORC1, which inhibits the autophagy pathway

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Preclinical studies indicate that systemic glutamine deprivation may induce muscle atrophy and intestinal mucosal damage (7), while high-dose administration of the ammonia scavenger sodium phenylbutyrate carries a risk of neurotoxicity (128)