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However, in chronic viral infection or cancer, TIM3 contributes to T cell exhaustion.[ref] CTLA4 (Cytotoxic T-lymphocyte-associated protein 4): CTLA4 is another negative regulator of the immune system
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The GSS gene encodes the glutathione synthetase enzyme (GSS), a critical player in the synthesis of GSH (Lu, 2013) Polymorphisms rs121909307 in the GSS gene can impact the activity of the GSS enzyme, influencing the production of GSH and, consequently, the cellular response to oxidative stress
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