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Disclosures: Anil Kharga: Nothing to Disclose, Huyun Chen: Nothing to Disclose, McLean Taggart: Nothing to Disclose, Mohammadreza Mojoudi: Nothing to Disclose, Alban Longchamp: Nothing to Disclose, Heidi Yeh: Nothing to Disclose, Korkut Uygun: Nothing to Disclose, James Markmann: Transmedics: stock, Vertex: Advisor, Transmedics: Advisor, iTolerance: Advisor, eGenesis: Advisor 1306 ESTABLISHMENT AND OBSERVATION OF A LONG-TERM VIABLE ALLOGENIC MURINE LIVER TRANSPLANTATION MODEL Keiko Iwaisako 1 Momoko Fujita 1 Kaito Suzumura 2 Shuhei kanda 3 Daisuke Kyuno 4 Hiroto Nishino 3 , 1 Faculty of Life and Medical Sciences, Doshisha University, 2 Graduate School of Life and Medical Sciences, Doshisha University, 3 Graduate School of Medicine, Kyoto University, 4 Sapporo Medical University Background: Immune rejection after liver transplantation remains largely unknown, and there are cases of chronic rejection that are difficult to treat, so there is a need to elucidate the mechanism and develop effective treatments

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In a phase 2 trial, once-weekly cagrilintide produced dose-dependent weight reductions in people with overweight or obesity, which is what moved the amylin pathway into serious combination development ( Lau et al., Lancet 2021 )