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AOD‑9604, by contrast, is not FDA‑approved as an obesity medication, and while safety data are reassuring, its use for weight loss remains off‑label with mixed evidence for effectiveness

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Similarly, the quinolinium containing parent analogue 1-MQ also lacked passive diffusion properties (Table 1), suggesting that the lipophilicity and drug-like permeability properties of analogues within the methylquinolinium series had to be improved via chemical modification