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Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts
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Similarly, treating colon carcinoma cells (Caco-2) with Spirulina (1.25–5% v / v , 72 h) increased nitric oxide (NO) and ROS production, while superoxide dismutase (SOD) levels decreased by approximately 50%, leading to impaired mitochondrial function and an increased Bax/Bcl-2 ratio [66]
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